Characterisation of collagen-producing cells in human peritoneal adhesions.
Caterina P, Mutsaers SE

The aim of this study is to characterise cell types within human peritoneal adhesions and identify cells likely to be synthesising collage, the scaffold for adhesions formation.

A time-course study of the morphological changes of apoptosis in fibroblasts from healthy human lung and from human lung affected by cryptogenic fibrosing alveolitis (CFA).
Moodley Y, Caterina P

The aim of this study is to identify at the ultrastructural level, the morphological changes of apoptosis, over a time course, in human healthy lung fibroblasts and with CFA lung fibroblasts.

Clinicopathological, immunohistochemical and ultrastructural study of perineurioma.
Rankine A, Spagnolo DV

Perineurioma is a rare, benign soft tissue tumour which may mimic a large number of other more common tumours, some of which are malignant. Misdiagnosis as a malignant tumour may lead to inappropriately aggressive treatment. This study aims to review comprehensively the clinicopathological features of a number of these tumours, and to establish reproducible diagnostic criteria to enable its distinction from other tumours with which it may be confused.

Gastrointestinal stromal tumours (GIST): a clinicopathological and molecular study of 66 cases.
Koay MHE, Goh Y-W, Iacopetta B, Segal A, Sterrett GF, Spagnolo DV

Gastrointestinal stromal tumours are uncommon mesenchymal tumours of the gastrintestinal tract, which until recently were often misdiagnosed as smooth muscle neoplasms. Their accurate identification is critical as most harbour mutations in the c-KIT gene resulting in inappropriate tyrosine kinase activation thought to have oncogenic effects, which may now be blocked with a novel tyrosine kinase inhibitor. Predicting their clinical behaviour is difficult and criteria delineating benign from malignant cases are variable. The aim of this project is to define the clinicopathological and molecular features of a large number of GIST, and to identify any morphological or molecular characteristics predictive of clinical behaviour.